FOG: Paul B. Samollow


	Paul B. Samollow
	Rank	Professor
	Department	Veterinary Integrative Biosciences
	Phone	(979) 845-7095
	Fax	(979) 845-9972
	Email Address	psamollow@cvm.tamu.edu

Comparative functional genomics; structural organization of genetic material and its relationship to patterns of gene regulation and expression within and among species. Population genomics: genetic and ecological processes that influence the distribution of genetic diversity within and among population subdivisions in nature, and their roles in promoting population structuring, isolation, and speciation.

Research in my laboratory focuses primarily on the structure and function of the newly sequenced genome of the gray, short-tailed opossum, Monodelphis domestica, a small South American marsupial that serves as the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. Interest areas include linkage and physical map construction, genome annotation. EST discovery and documentation, sex-specific patterns of meiotic recombination, the marsupial MHC and other immune-related gene families, QTL mapping, and comparative vertebrate genome structure. Additional research topics include population-level (family-based) studies of the genetic basis and health implications of normal (non-pathologic) inter-individual variation in human thyroid hormone phenotypes, and the genetic origins of variation in susceptibility to environmentally induced melanoma and other neoplasias in interspecific hybrid models of the fish genus Xiphophorus (playtfishes and swordtails).

Samollow, P. B., C. M. Kammerer, S. M. Mahaney, J. L. Schneider, S. J. Westenberger, J. L. VandeBerg, and E. S. Robinson. 2004. First generation linkage map of the gray, short-tailed opossum, Monodelphis domestica, reveals genome-wide reduction in female recombination rates. Genetics: 166:307-329.

Samollow, P. B., G. Perez, C. M. Kammerer, D. Finegold, P. W. Zwartjes, L. M. Havill, A. G. Comuzzie, M. C. Mahaney, H. H. Goring, J. Blangero, T. P. Foley, and M. M. Barmada. 2004. Genetic and environmental influences on thyroid hormone variation in Mexican Americans. J. Clin. Endocrinol. Metab: 89:3276-3284.

Samollow, P. B. 2006 . Status and applications of genomic resources for the gray, short-tailed opossum, Monodelphis domestica, a marsupial model for comparative biology and genomic research. Aust. J. Zool. 54:173-196.

Gouin, N., J. E. Deakin, K. B. Miska, R. D. Miller, C. M. Kammerer, J. A. M. Graves, J. L. VandeBerg, and P. B. Samollow. 2006. Linkage mapping and physical localization of the major histocompatibility complex region of the marsupial Monodelphis domestica. Cytogenetic and Genome Research 112:277-285.

Hoppe, R., T. D. Lambert, P. B. Samollow, H. Breer, and J. Strotmann. 2006. Evolution of the 'OR37' subfamily of olfactory receptors: a cross species comparison. J. Molec. Evol. 62:460-472.

Belov K., J. E. Deakin, A. T. Papenfuss, M. L. Baker, S. D. Melman, H. V. Siddle, N. Gouin, D. L. Goode, T. J. Sargeant, M. D. Robinson, M. J. Wakefield, S. Mahony, J. G. Cross, P. V. Benos, P. B. Samollow, T. P. Speed, J. A. Graves, and R. D. Miller. 2006. Reconstructing an ancestral mammalian immune supercomplex from a marsupial MHC. PloS Biol. 4:e46 (Epub ahead of print).

Walter, R. B., Z. Ju, A. Martinez, C. Amemiya, and P. B. Samollow. 2006. Genomic Resources for Xiphophorus Research. Zebrafish 3:11-22