Terje Raudsepp

Rank

Assistant Professor

Department

Veterinary Integrated Biosciences (VIBS)

Phone

(979) 862 2879

Fax

(979) 845 9972

Email Address

traudsepp@cvm.tamu.edu


A variety of projects concentrate on different aspects of animal genome analysis: genome organization and evolution, construction of physical maps, study of functional profiles of individual genes and their association with inherited disorders and fertility problems.
Genome organization and physical maps: whole genome mapping in horse using a combination of approaches like radiation hybrid analysis, fluorescent in situ hybridization (FISH) and construction of contigs of overlapping BAC clones. The maps are used for the study of inherited disorders and fertility in horses, as well as, for the assembly of horse whole genome sequence map. We apply FISH also for mapping genes in other domestic (cattle, pig, dog, cat, chicken) and wild (zebras, giraffe, hippopotamus, California condor, etc.) animal species in order to study the organization and evolution of these genomes.
Analysis of mammalian sex chromosomes: generation of detailed maps for horse X and Y chromosomes. Comparative structural and functional study of Y chromosomes from a variety of species (horse, cattle, pig, cat, armadillo). Comparative analysis of pseudoautosomal regions in eutherian mammals.
Reproduction and sex determination related genes: study of Y chromosome factors that are associated with sex determination disorders (male and female sex reversal) and infertility in horses and other domestic species.
Cytogenetic analysis: chromosome analysis service for all domestic animals and some exotic species for the entire North America (USA, Canada) but also for other countries (New Zealand, Israel, Ireland, etc.).

  1. Pearks-Wilkerson AJ, Raudsepp T, Graves T, Albracht D, Warren W, Chowdhary BP, Skow LC & Murphy WJ (2008) Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome. Genomics
  2. Raudsepp T & Chowdhary BP (2008) FISH for mapping single copy genes. Methods Mol Biol 422: 31-49
  3. Raudsepp T & Chowdhary BP (2008) The horse pseudoautosomal region (PAR): characterization and comparison with the human, chimp and mouse PARs. Cytogenet Genome Res 121: 102-9
  4. Chowdhary BP, Paria N & Raudsepp T (2008) Potential applications of equine genomics in dissecting diseases and fertility. Anim Reprod Sci 107: 208-18
  5. Brinkmeyer-Langford C, Raudsepp T, Gustafson-Seabury A & Chowdhary BP (2008) A BAC contig map over the proximal approximately 3.3 Mb region of horse chromosome 21. Cytogenet Genome Res 120: 164-72
  6. Chowdhary BP & Raudsepp T (2008) The horse genome derby: racing from map to whole genome sequence. Chromosome Res 16: 109-27
  7. Chiang HI, Zhou H, Raudsepp T, Jesudhasan PR & Zhu JJ (2007) Chicken CD69 and CD94/NKG2-like genes in a chromosomal region syntenic to mammalian natural killer gene complex. Immunogenetics 59: 603-11
  8. Hansen GR, Abbey CA, Gaile DP, Raudsepp T, Chowdhary BP, Womack JE & Gill CA (2007) Assignment of six genes to bovine chromosomes 5 and 16 by fluorescence in situ hybridization, radiation hybrid mapping and genetic linkage analysis. Cytogenet Genome Res 116: 194-7
  9. Momozawa Y, Takeuchi Y, Tozaki T, Kikusui T, Hasegawa T, Raudsepp T, Chowdhary BP, Kusunose R & Mori Y (2007) SNP detection and radiation hybrid mapping in horses of nine candidate genes for temperament. Anim Genet 38: 81-3
  10. Goh G, Raudsepp T, Durkin K, Wagner ML, Schäffer AA, Agarwala R, Tozaki T, Mickelson JR & Chowdhary BP (2007) High-resolution gene maps of horse chromosomes 14 and 21: additional insights into evolution and rearrangements of HSA5 homologs in mammals. Genomics 89: 89-112
  11. Momozawa Y, Takeuchi Y, Tozaki T, Kikusui T, Hasegawa T, Raudsepp T, Chowdhary BP, Kusunose R & Mori Y (2006) Polymorphism identification, RH mapping, and association analysis with the anxiety trait of the equine serotonin transporter (SLC6A4) gene. J Vet Med Sci 68: 619-21
  12. Dranchak PK, Ekenstedt KJ, Valberg SJ, Chowdhary BP, Raudsepp T & Mickelson JR (2006) Chromosomal assignments for the equine AMPK family genes. Anim Genet 37: 293-4
  13. Murphy WJ, Pearks Wilkerson AJ, Raudsepp T, Agarwala R, Schäffer AA, Stanyon R & Chowdhary BP (2006) Novel gene acquisition on carnivore Y chromosomes. PLoS Genet 2: e43
  14. Perrocheau M, Boutreux V, Chadi S, Mata X, Decaunes P, Raudsepp T, Durkin K, Incarnato D, Iannuzzi L, Lear TL, Hirota K, Hasegawa T, Zhu B, de Jong P, Cribiu EP, Chowdhary BP & Guérin G (2006) Construction of a medium-density horse gene map. Anim Genet 37: 145-55
  15. Wagner ML, Raudsepp T, Goh G, Agarwala R, Schaffer AA, Dranchak PK, Brinkmeyer-Langford C, Skow LC, Chowdhary BP & Mickelson JR (2006) A 1.3-Mb interval map of equine homologs of HSA2. Cytogenet Genome Res 112: 227-34
  16. Carbone L, Nergadze SG, Magnani E, Misceo D, Francesca Cardone M, Roberto R, Bertoni L, Attolini C, Francesca Piras M, de Jong P, Raudsepp T, Chowdhary BP, Guérin G, Archidiacono N, Rocchi M & Giulotto E (2006) Evolutionary movement of centromeres in horse, donkey, and zebra. Genomics 87: 777-82
  17. Swinburne JE, Boursnell M, Hill G, Pettitt L, Allen T, Chowdhary B, Hasegawa T, Kurosawa M, Leeb T, Mashima S, Mickelson JR, Raudsepp T, Tozaki T & Binns M (2006) Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families. Genomics 87: 1-29
  18. Brinkmeyer-Langford C, Raudsepp T, Lee EJ, Goh G, Schäffer AA, Agarwala R, Wagner ML, Tozaki T, Skow LC, Womack JE, Mickelson JR & Chowdhary BP (2005) A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals. Mamm Genome 16: 631-49
  19. Murphy WJ, Larkin DM, Everts-van der Wind A, Bourque G, Tesler G, Auvil L, Beever JE, Chowdhary BP, Galibert F, Gatzke L, Hitte C, Meyers SN, Milan D, Ostrander EA, Pape G, Parker HG, Raudsepp T, Rogatcheva MB, Schook LB, Skow LC, Welge M, Womack JE, O'brien SJ, Pevzner PA & Lewin HA (2005) Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science 309: 613-7
  20. Lagerström MC, Fredriksson R, Bjarnadóttir TK, Fridmanis D, Holmquist T, Andersson J, Yan YL, Raudsepp T, Zoorob R, Kukkonen JP, Lundin LG, Klovins J, Chowdhary BP, Postlethwait JH & Schiöth HB (2005) Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. Genomics 85: 688-703

Publications list from Pubmed
 
Faculty of Genetics : Texas A&M University �2004
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