Terje Raudsepp

Rank

Assistant Professor

Department

Veterinary Integrated Biosciences (VIBS)

Phone

(979) 862 2879

Fax

(979) 845 9972

Email Address

traudsepp@cvm.tamu.edu


A variety of projects concentrate on different aspects of animal genome analysis: genome organization and evolution, construction of physical maps, study of functional profiles of individual genes and their association with inherited disorders and fertility problems.
Genome organization and physical maps: whole genome mapping in horse using a combination of approaches like radiation hybrid analysis, fluorescent in situ hybridization (FISH) and construction of contigs of overlapping BAC clones. The maps are used for the study of inherited disorders and fertility in horses, as well as, for the assembly of horse whole genome sequence map. We apply FISH also for mapping genes in other domestic (cattle, pig, dog, cat, chicken) and wild (zebras, giraffe, hippopotamus, California condor, etc.) animal species in order to study the organization and evolution of these genomes.
Analysis of mammalian sex chromosomes: generation of detailed maps for horse X and Y chromosomes. Comparative structural and functional study of Y chromosomes from a variety of species (horse, cattle, pig, cat, armadillo). Comparative analysis of pseudoautosomal regions in eutherian mammals.
Reproduction and sex determination related genes: study of Y chromosome factors that are associated with sex determination disorders (male and female sex reversal) and infertility in horses and other domestic species.
Cytogenetic analysis: chromosome analysis service for all domestic animals and some exotic species for the entire North America (USA, Canada) but also for other countries (New Zealand, Israel, Ireland, etc.).

  1. Schneider DA, Tibary A, Raudsepp T, Das PJ & O'Rourke KI (2009) Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep. J Vet Diagn Invest 21: 295-305
  2. Brinkmeyer-Langford CL, Childers CP, Fritz KL, Gustafson-Seabury AL, Cothran M, Raudsepp T, Womack JE & Skow LC (2009) A high resolution RH map of the bovine major histocompatibility complex. BMC Genomics 10: 182
  3. Alizadeh A, Hong LZ, Kaelin CB, Raudsepp T, Manuel H & Barsh GS (2009) Genetics of Sex-linked yellow in the Syrian hamster. Genetics 181: 1427-36
  4. Liu J, Westhusin M, Johnson G, Raudsepp T, Chowdhary B, Burghardt R, Long C & Kraemer D (2008) Evaluation of culture systems for attachment and proliferation of epithelial cells cultured from ovine semen. Anim Reprod Sci
  5. Davis BW, Raudsepp T, Pearks Wilkerson AJ, Agarwala R, Schäffer AA, Houck M, Chowdhary BP & Murphy WJ (2009) A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae. Genomics 93: 299-304
  6. Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer-Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H, Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR & Chowdhary BP (2008) A 4,103 marker integrated physical and comparative map of the horse genome. Cytogenet Genome Res 122: 28-36
  7. Chowdhary BP & Raudsepp T (2006) The horse genome. Genome Dyn 2: 97-110
  8. Pearks Wilkerson AJ, Raudsepp T, Graves T, Albracht D, Warren W, Chowdhary BP, Skow LC & Murphy WJ (2008) Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome. Genomics 92: 329-38
  9. Raudsepp T & Chowdhary BP (2008) FISH for mapping single copy genes. Methods Mol Biol 422: 31-49
  10. Raudsepp T & Chowdhary BP (2008) The horse pseudoautosomal region (PAR): characterization and comparison with the human, chimp and mouse PARs. Cytogenet Genome Res 121: 102-9
  11. Chowdhary BP, Paria N & Raudsepp T (2008) Potential applications of equine genomics in dissecting diseases and fertility. Anim Reprod Sci 107: 208-18
  12. Brinkmeyer-Langford C, Raudsepp T, Gustafson-Seabury A & Chowdhary BP (2008) A BAC contig map over the proximal approximately 3.3 Mb region of horse chromosome 21. Cytogenet Genome Res 120: 164-72
  13. Chowdhary BP & Raudsepp T (2008) The horse genome derby: racing from map to whole genome sequence. Chromosome Res 16: 109-27
  14. Chiang HI, Zhou H, Raudsepp T, Jesudhasan PR & Zhu JJ (2007) Chicken CD69 and CD94/NKG2-like genes in a chromosomal region syntenic to mammalian natural killer gene complex. Immunogenetics 59: 603-11
  15. Hansen GR, Abbey CA, Gaile DP, Raudsepp T, Chowdhary BP, Womack JE & Gill CA (2007) Assignment of six genes to bovine chromosomes 5 and 16 by fluorescence in situ hybridization, radiation hybrid mapping and genetic linkage analysis. Cytogenet Genome Res 116: 194-7
  16. Momozawa Y, Takeuchi Y, Tozaki T, Kikusui T, Hasegawa T, Raudsepp T, Chowdhary BP, Kusunose R & Mori Y (2007) SNP detection and radiation hybrid mapping in horses of nine candidate genes for temperament. Anim Genet 38: 81-3
  17. Goh G, Raudsepp T, Durkin K, Wagner ML, Schäffer AA, Agarwala R, Tozaki T, Mickelson JR & Chowdhary BP (2007) High-resolution gene maps of horse chromosomes 14 and 21: additional insights into evolution and rearrangements of HSA5 homologs in mammals. Genomics 89: 89-112
  18. Momozawa Y, Takeuchi Y, Tozaki T, Kikusui T, Hasegawa T, Raudsepp T, Chowdhary BP, Kusunose R & Mori Y (2006) Polymorphism identification, RH mapping, and association analysis with the anxiety trait of the equine serotonin transporter (SLC6A4) gene. J Vet Med Sci 68: 619-21
  19. Dranchak PK, Ekenstedt KJ, Valberg SJ, Chowdhary BP, Raudsepp T & Mickelson JR (2006) Chromosomal assignments for the equine AMPK family genes. Anim Genet 37: 293-4
  20. Murphy WJ, Pearks Wilkerson AJ, Raudsepp T, Agarwala R, Schäffer AA, Stanyon R & Chowdhary BP (2006) Novel gene acquisition on carnivore Y chromosomes. PLoS Genet 2: e43

Publications list from Pubmed
 
Faculty of Genetics : Texas A&M University �2004
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